Description

2-Deoxy-D-Glucose-[3H(G)] is a tritium-labeled analog of 2-deoxy-D-glucose, a well-characterized glucose metabolism inhibitor. This radiolabeled compound is essential for advanced metabolic research, enabling precise tracking and quantification of glucose uptake and utilization in biological systems. It is a critical tool for researchers and pharmaceutical developers in oncology, neurology, and metabolic disease studies who require high-specific-activity tracers for autoradiography, cell-based assays, and in vivo imaging.

Application

• Metabolic Pathway Tracing: Used as a radiotracer in studies of glycolysis, hexokinase activity, and the pentose phosphate pathway.
• Cancer Research: Employed in vitro and in vivo to study the Warburg effect, tumor cell metabolism, and to evaluate the efficacy of glycolytic inhibitors.
• Drug Discovery & Development: Serves as a key reagent in high-throughput screening assays for identifying novel therapeutic agents targeting glucose metabolism.
• Molecular Imaging: Facilitates quantitative autoradiography and supports the development of companion diagnostics for PET imaging.
• Cellular Bioenergetics: Used to assess cellular glucose uptake under various physiological and pathological conditions.

Basic Information

Product Name	2-Deoxy-D-Glucose-[3H(G)]
CAS No.	37090-87-2
Molecular Formula	C6H113HO5
Molecular Weight	~164.16 g/mol (unlabeled)
Synonyms	2-Deoxy-D-[3H]Glucose; 2-DG-[3H]; D-[3H]-2-Deoxyglucose; [3H]2DG; 2-Deoxy-D-arabino-hexose-[3H(G)]; Tritiated 2-Deoxy-D-glucose; 2-Deoxyglucose, D-[3H(G)]-; Radiolabeled 2-DG
EINECS	Contact for details

Quality Control

Every batch of 2-Deoxy-D-Glucose-[3H(G)] is manufactured and analyzed under strict quality systems. Radiochemical purity and specific activity are determined using validated methods such as HPLC with radiometric detection. Our products undergo rigorous quality testing to ensure compliance with industry standards for research chemicals. Certificates of Analysis (COA) detailing specific activity, purity, solvent, and concentration are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as supplied. For long-term storage, keep at -70°C to -80°C. Due to its highly volatile nature (tritium label), appropriate laboratory containment and ventilation procedures must be followed. Always handle in accordance with local radiation safety regulations.

Specification

Item	Specification
Appearance	Clear, colorless solution
Identification (HPLC)	Conforms to reference standard
Specific Activity	10-40 Ci/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Concentration	1 mCi/mL (in ethanol:water solution)
Solvent	Ethanol:Water (9:1 v/v)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.