Description

Tegafur CAS NO 37076-68-9 is a fluorinated pyrimidine derivative and a prodrug of the antineoplastic agent 5-fluorouracil (5-FU). This compound is critically important in oncology for its role in targeted cancer chemotherapy, offering a mechanism for the controlled release of the active cytotoxic metabolite. It is primarily required by the pharmaceutical industry for the formulation of oral and injectable chemotherapeutic agents, as well as by research institutions engaged in developing novel anticancer therapies and drug delivery systems.

Application

• Oncological Pharmaceutical Manufacturing: As an active pharmaceutical ingredient (API) in oral capsules and tablets for the treatment of various cancers, including colorectal, gastric, and breast cancer.
• Injectable Chemotherapy Formulations: Used in the production of sterile injectable solutions for clinical administration.
• Combination Therapy Development: A key component in combination regimens, such as with gimeracil and oteracil (S-1 therapy), to enhance efficacy and modulate toxicity.
• Biomedical Research: Employed as a reference standard and experimental compound in preclinical studies to investigate mechanisms of action, drug resistance, and new therapeutic applications.
• Drug Delivery System R&D: Used in the development of novel delivery platforms like liposomes, nanoparticles, or implants designed for sustained or targeted release.
• Analytical and Quality Control: Serves as a high-purity standard for HPLC, LC-MS, and other analytical methods in pharmaceutical QC/QA laboratories.

Basic Information

Product Name	Tegafur
CAS No.	37076-68-9
Molecular Formula	C8H9FN2O3
Molecular Weight	200.17 g/mol
Synonyms	5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione; FT-207; Ftorafur; 1-(2-Tetrahydrofuryl)-5-fluorouracil; NSC-148958; Fluorofur; Futraful; Sunfural
EINECS	253-344-8

Quality Control

Our Tegafur is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with various pharmacopeial monographs, and specifications can be tailored to meet specific customer requirements for research or GMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.