Description

1,2-Didocosanoyl-Sn-Glycero-3-Phosphocholine is a high-purity, synthetic phospholipid belonging to the phosphatidylcholine (PC) class, specifically a distearoyl phosphatidylcholine analog with very long-chain behenic acid (docosanoic acid, C22:0) fatty acyl groups. This compound is critical for creating highly stable, impermeable lipid bilayers in advanced biomimetic membrane research and pharmaceutical formulation development. It is essential for researchers and manufacturers in the liposome and nanoparticle drug delivery, membrane biophysics, and diagnostic reagent sectors who require lipids with high phase transition temperatures for enhanced formulation stability.

Application

• Liposome and Lipid Nanoparticle (LNP) Formulation: As a primary structural phospholipid for creating rigid, stable vesicles for sustained-release drug delivery systems and mRNA vaccine carriers.
• Biomimetic Membrane Models: Used in solid-supported lipid bilayers (SLBs) and giant unilamellar vesicles (GUVs) to study membrane protein interactions, permeability, and mechanics due to its high melting point.
• Diagnostic Reagents: A key component in the formulation of control lipids and calibrators for clinical diagnostic assays targeting phospholipid metabolism.
• Cochleate and Micelle Stabilization: Employed to formulate stable cochleate cylinders or micelles for the encapsulation of hydrophobic active pharmaceutical ingredients (APIs).
• Cosmetic Actives Delivery: Used in high-end cosmetic formulations to create stable nanocarriers for the targeted delivery of vitamins and anti-aging compounds.
• Reference Standard: Serves as a high-purity analytical standard in lipidomics research and quality control testing for lipid-based products.

Basic Information

Item	Details
Product Name	1,2-Didocosanoyl-Sn-Glycero-3-Phosphocholine
CAS No.	37070-48-7
Molecular Formula	C52H104NO8P
Molecular Weight	902.36 g/mol
Synonyms	1,2-Dibehenoyl-sn-glycero-3-phosphocholine; DSPC (C22:0); DBPC; 1,2-Didocosanoylphosphatidylcholine; PC(22:0/22:0); Phosphatidylcholine, 1,2-didocosanoyl-; Behenoyl Phosphatidylcholine; L-α-Phosphatidylcholine, 1,2-didocosanoyl-
EINECS	Contact for details

Quality Control

Our 1,2-Didocosanoyl-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, identity, and impurity profiles. We support compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) to prevent oxidation and hydrolysis. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, light, or ambient temperature will degrade product quality. Allow the sealed container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Phase Transition Temperature (Tm)	Contact for details
Solubility	Soluble in chloroform, slightly soluble in ethanol, insoluble in water
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	< 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.