Description

4-Methylumbelliferyl-n-Acetyl-β-D-Glucosaminide is a specialized fluorogenic substrate used for the detection and quantification of N-acetyl-β-D-glucosaminidase (NAGase) activity. This compound is critical for researchers and diagnostic manufacturers requiring high-purity, reliable enzyme substrates for sensitive biochemical assays. It is primarily utilized in life science research, clinical diagnostics, and pharmaceutical development for studying lysosomal function and enzyme kinetics.

Application

• Enzyme Activity Assays: Primary fluorogenic substrate for measuring N-acetyl-β-D-glucosaminidase (NAGase) activity in research and diagnostic kits.
• Clinical Diagnostics: Used in the detection of lysosomal storage disorders and as a biomarker for renal tubular damage.
• Biochemical Research: Essential tool for studying carbohydrate metabolism, enzyme inhibition, and lysosomal biology in vitro.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify potential therapeutic modulators of NAGase.
• Microbiology: Can be used in assays to study enzyme activity in microbial systems.
• Quality Control: Serves as a reference standard in the production and validation of diagnostic reagents.

Basic Information

Product Name	4-Methylumbelliferyl-n-Acetyl-β-D-Glucosaminide
CAS No.	37067-30-4
Molecular Formula	C18H21NO9
Molecular Weight	395.36 g/mol
Synonyms	4-MU-β-GlcNAc; 4-Methylumbelliferyl N-acetyl-β-D-glucosaminide; 4-Methylumbelliferyl 2-acetamido-2-deoxy-β-D-glucopyranoside; NAG-4MU; 4-MU-GlcNAc; 4-Methylumbelliferyl β-N-acetylglucosaminide; 4-Methylumbelliferyl N-acetyl-β-D-glucosaminide (enzymatic substrate)
EINECS	Contact for details

Quality Control

Our 4-Methylumbelliferyl-n-Acetyl-β-D-Glucosaminide is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research and diagnostic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and performance in standard enzyme assays. We adhere to relevant quality guidelines to support our global customer base.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to moisture or light should be avoided to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Fluorogenic Activity	Conforms to reference standard
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.