Description

(-)-1,4-Di-o-Tosyl-2,3-o-Isopropylidenethreitol is a high-purity, chiral synthetic intermediate of significant importance in advanced organic synthesis. Its core value lies in its utility as a key building block for constructing complex molecules with defined stereochemistry, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for producing active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of complex drug candidates, particularly for antiviral, anticancer, and other therapeutic agents.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic and stoichiometric asymmetric reactions to introduce specific stereocenters.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.
• Natural Product Synthesis: Employed in the total synthesis of natural products that contain threitol or related polyol motifs.
• Agrochemical Research: Used in the development of chiral active ingredients for crop protection products.
• Material Science: Potential monomer or cross-linker for creating specialized polymers with specific optical or physical properties.

Basic Information

Product Name	(-)-1,4-Di-o-Tosyl-2,3-o-Isopropylidenethreitol
CAS No.	37002-45-2
Molecular Formula	C22H26O7S2
Molecular Weight	466.57 g/mol
Synonyms	(2R,3R)-1,4-Bis(4-methylbenzenesulfonyloxy)-2,3-O-isopropylidene-1,2,3,4-butanetetrol; (2R,3R)-1,4-Bis(p-toluenesulfonyloxy)-2,3-O-isopropylidene-1,2,3,4-butanetetrol; (-)-1,4-Di-O-tosyl-2,3-O-isopropylidene-L-threitol; L-Threitol, 1,4-bis(p-toluenesulfonate) 2,3-isopropylidene acetal; 1,4-Di-O-tosyl-2,3-O-isopropylidene-L-threitol; DITOL; (2R,3R)-1,4-Bis[(4-methylphenyl)sulfonyl]oxy-2,3-(1-methylethylidenedioxy)butane
EINECS	Contact for details

Quality Control

Our (-)-1,4-Di-o-Tosyl-2,3-o-Isopropylidenethreitol is manufactured under strict quality control protocols to ensure high chemical purity and chiral integrity, suitable for demanding synthetic applications. Each batch is analyzed using advanced techniques including HPLC, NMR, and optical rotation measurement to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.