Description

1-Chloro-3,5-Difluoro-2-Nitrobenzene is a versatile halogenated nitrobenzene derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for creating complex molecules with tailored properties. This compound is primarily utilized by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing difluorophenyl and nitroaryl motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the chloro and fluoro substituents enhance biological activity and stability.
• Material Science Precursor: Serves as a starting material for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Employed in the synthesis of complex organic dyes and pigments due to its nitro and halogen functional groups.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form biaryl structures.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	1-Chloro-3,5-Difluoro-2-Nitrobenzene
CAS No.	36556-55-5
Molecular Formula	C6H2ClF2NO2
Molecular Weight	193.54 g/mol
Synonyms	2-Nitro-1-chloro-3,5-difluorobenzene; 3,5-Difluoro-2-nitrochlorobenzene; 1-Chloro-3,5-difluoro-2-nitro-benzene; Benzene, 1-chloro-3,5-difluoro-2-nitro-; 2-Chloro-1,3-difluoro-4-nitrobenzene (isomer); 36556-55-5; 3,5-Difluoro-2-nitro-1-chlorobenzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-3,5-Difluoro-2-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request for every shipment, providing full traceability and compliance documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.