Description

9-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione Mono(Hydrogen Sulphate) CAS NO 36493-04-6 is a high-purity synthetic corticosteroid derivative, specifically a sulfate ester of dexamethasone. This compound is a critical advanced pharmaceutical intermediate, valued for its role in the synthesis of more complex, potent, and targeted steroid-based therapeutics. It is essential for research and development laboratories, as well as manufacturing facilities, operating in the pharmaceutical and fine chemical sectors, where precise molecular structure and high purity are non-negotiable for successful drug development and regulatory approval.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel, high-potency corticosteroid drugs and prodrugs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new anti-inflammatory and immunosuppressive agents.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry: Employed in scaling up synthetic routes for the commercial production of specialty steroid APIs (Active Pharmaceutical Ingredients).
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor interactions and metabolic pathways.

Basic Information

Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione Mono(Hydrogen Sulphate)
CAS No.	36493-04-6
Molecular Formula	C22H29FO8S
Molecular Weight	472.52 g/mol
Synonyms	Dexamethasone 21-Sulfate; Dexamethasone Hydrogen Sulfate; 9α-Fluoro-16α-methylprednisolone 21-Sulfate; 16α-Methyl-9α-fluoroprednisolone 21-Sulfate; (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-(Hydrogen Sulfate); Prednisolone, 9-fluoro-16-methyl-21-sulfate, (11β,16α)-; Dexamethasone 21-(Hydrogen Sulfate) Ester
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione Mono(Hydrogen Sulphate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards suitable for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.