Description

1,2-Dihexadecyl-Sn-Glycero-3-Phosphocholine Dihydrate is a high-purity, synthetic phospholipid, specifically a saturated phosphatidylcholine, widely used as a critical component in the formulation of model membranes and advanced drug delivery systems. Its consistent molecular structure and high chemical purity make it an essential material for research and development in life sciences and pharmaceutical manufacturing. This compound is particularly valuable for scientists and manufacturers working on liposome-based therapeutics, vaccine adjuvants, and membrane biophysics studies, where precise lipid composition is paramount for reproducibility and efficacy.

Application

• Liposome Formulation: A primary building block for creating stable, unilamellar vesicles used in drug delivery for cancer therapies, gene therapy, and mRNA vaccines.
• Model Membrane Systems: Used to create planar lipid bilayers and supported membranes for biophysical studies of protein-lipid interactions and membrane permeability.
• Pharmaceutical Excipient: Serves as a key structural lipid in the manufacture of lipid nanoparticles (LNPs) and other nano-carrier systems.
• Biochemical Research: Essential for studying lipid raft domains, membrane fluidity, and the behavior of integral membrane proteins in a controlled environment.
• Diagnostic Reagents: Used in the development of diagnostic assays and kits that utilize membrane-based detection technologies.
• Cosmetic & Dermal Delivery: Incorporated into advanced cosmetic formulations for enhanced skin penetration and stabilization of active ingredients.

Basic Information

Item	Details
Product Name	1,2-Dihexadecyl-Sn-Glycero-3-Phosphocholine Dihydrate
CAS No.	36314-47-3
Molecular Formula	C40H86NO8P • 2H2O
Molecular Weight	758.10 g/mol (Anhydrous basis: 722.08)
Synonyms	Dipalmitoylphosphatidylcholine, DPPC, 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine, 1,2-Dihexadecanoyl-sn-glycero-3-phosphocholine, L-α-Dipalmitoylphosphatidylcholine, Phosphatidylcholine, 1,2-dihexadecanoyl-, (R)-, Dipalmitoyl Lecithin
EINECS	Contact for details

Quality Control

Every batch of our 1,2-Dihexadecyl-Sn-Glycero-3-Phosphocholine Dihydrate is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure it meets the rigorous standards required for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity, identity, and residual solvents. Our quality protocols are designed to support compliance with cGMP and ICH guidelines for advanced therapeutic medicinal products (ATMPs).

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. For short-term use, the material may be stored at 2-8°C. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	4.5 - 5.5% (corresponding to dihydrate)
Residual Solvents (GC)	Meets ICH limits
Phase Transition Temperature (DSC)	41°C ± 2°C
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.