Description

12-o-Acetyllycocernuine CAS NO 36101-26-5 is a specific acetylated derivative of the Lycopodium alkaloid lycocernuine, representing a high-purity reference standard and research chemical. This compound is critical for pharmaceutical research and development, particularly in the study of acetylcholinesterase inhibition and neuropharmacology. It is primarily utilized by research institutions, pharmaceutical companies, and analytical laboratories engaged in neuroscience, natural product chemistry, and drug discovery programs.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the qualitative and quantitative analysis of related alkaloids in research and quality control.
• Neuroscience Research: Used as a key intermediate or probe in studies investigating acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition for potential therapeutic applications.
• Natural Product Chemistry: Employed in the isolation, structural elucidation, and synthetic studies of complex Lycopodium alkaloids.
• Bioactivity Screening: A vital component in high-throughput screening libraries for identifying novel bioactive compounds targeting neurological pathways.
• Analytical Method Development: Used to develop and validate chromatographic methods (HPLC, LC-MS) for the detection of alkaloids in complex matrices.

Basic Information

Product Name	12-o-Acetyllycocernuine
CAS No.	36101-26-5
Molecular Formula	C18H27NO4
Molecular Weight	321.41 g/mol
Synonyms	12-O-Acetyllycocernuine; 12-Acetoxylycocernuine; Lycocernuine 12-acetate; (1R,2R,4aS,5S,6R,7R,8aS)-5-(Acetyloxy)-2-ethyl-1,2,3,4,4a,5,6,7,8,8a-decahydro-6-methyl-1,4a,6-trimethylenenaphthalen-7-ol; 12-O-Acetyl-lycocernuine
EINECS	Contact for details

Quality Control

Our 12-o-Acetyllycocernuine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific pharmacopoeial or internal standards are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.