Description

4-Deoxyevonine is a naturally derived steroidal alkaloid isolated from plants of the Evolvulus and Convolvulus genera, structurally characterized by the absence of a hydroxyl group at the C-4 position of the evonine scaffold. It serves as a high-value intermediate in the synthesis of bioactive compounds for pharmaceutical research, particularly in neuropharmacology and anti-inflammatory drug discovery. Researchers and contract development organizations (CDOs) engaged in natural product derivatization, structure–activity relationship (SAR) studies, and preclinical candidate optimization rely on rigorously characterized 4-Deoxyevonine CAS NO 36017-50-2 for reproducible experimental outcomes.

Application

• Pharmaceutical R&D: Key synthetic intermediate for novel steroidal alkaloid analogs targeting nicotinic acetylcholine receptors (nAChRs)
• Neuroscience research: Probe compound in studies of cognitive enhancement and neuroprotection pathways
• Anti-inflammatory drug discovery: Scaffold for developing selective COX-2/LOX dual inhibitors
• Natural product total synthesis: Chiral building block in multi-step routes to complex evonine-type alkaloids
• Reference standard for HPLC and LC-MS method validation in phytochemical analysis
• Biological assay calibration: Used as a quantitative control in cytotoxicity and receptor binding assays
• Academic medicinal chemistry programs: Teaching and research material for advanced organic synthesis laboratories

Basic Information

Product Name	4-Deoxyevonine
CAS No.	36017-50-2
Molecular Formula	C27H41NO3
Molecular Weight	427.62 g/mol
Synonyms	4-Deoxyevonine; Evonine-4-deoxy; 4-Desoxyevonine; (3β,5α,17α,20R)-3-(Acetyloxy)-20-(dimethylamino)-5-hydroxy-17-methyl-2-oxa-17-aza-bicyclo[10.2.2]hexadecan-16-one; NSC 118917; UNII-7QZ7K1V9WJ; CHEMBL1201531; ZINC13542542
EINECS	252-797-0

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are tested per ICH Q2(R2) guidelines for identification, assay, and impurity profiling. Testing includes HPLC purity assessment, chiral integrity verification, residual solvent analysis (per ICH Q3C), and heavy metals screening (USP <232>/<233>). Complies with ISO 9001-certified manufacturing protocols and supports GMP-aligned research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (nitrogen or argon) to prevent oxidation. Keep away from strong acid/organic solvent and fluoride/strong alkali environments. Maintain low humidity conditions to avoid potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Specific Rotation	[α]D20 = –24° to –28° (c = 1 in CHCl3)
Residual Solvents	Meets ICH Q3C Class 3 limits
Heavy Metals	≤ 10 ppm
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.