Description

(20R)-17,20-Epoxy-19,20-Dihydro-18-Hydroxysarpagane-16-Carboxylic Acid Methyl Ester CAS NO 35594-10-6 is a high-purity, complex indole alkaloid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical chiral building block and key synthetic intermediate for the development of novel bioactive molecules. It is primarily required by research institutions and pharmaceutical companies engaged in the synthesis of complex natural products and the exploration of new therapeutic agents targeting neurological and cardiovascular systems.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex indole alkaloids and their analogs for pharmacological evaluation.
• Medicinal Chemistry Research: Used as a scaffold or chiral template for designing and synthesizing new chemical entities (NCEs) in drug discovery programs.
• Natural Product Synthesis: Serves as a key intermediate in the total or semi-synthesis of sarpagine- and ajmaline-related alkaloids.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme interactions or receptor binding mechanisms related to its structural class.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in laboratories.
• Asymmetric Synthesis: Utilized in stereoselective synthesis due to its defined (20R) configuration, enabling the construction of complex chiral centers.

Basic Information

Product Name	(20R)-17,20-Epoxy-19,20-Dihydro-18-Hydroxysarpagane-16-Carboxylic Acid Methyl Ester
CAS No.	35594-10-6
Molecular Formula	C21H26N2O4
Molecular Weight	370.45 g/mol
Synonyms	Methyl (20R)-17,20-epoxy-19,20-dihydro-18-hydroxysarpagan-16-carboxylate; 18-Hydroxy-17,20-epoxysarpagan-16-carboxylic acid methyl ester; Sarpagan-16-carboxylic acid, 17,20-epoxy-19,20-dihydro-18-hydroxy-, methyl ester, (20R)-; Ajmaline derivative intermediate; 16-Carbomethoxysarpagan-17,20-epoxide; (20R)-17,20α-Epoxy-19,20-dihydro-18-hydroxysarpagan-16-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our (20R)-17,20-Epoxy-19,20-Dihydro-18-Hydroxysarpagane-16-Carboxylic Acid Methyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is characterized and released with a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles for laboratory-scale synthesis to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.