Description

3-Keto Sphinganine (D18:0) (Hydrochloride) is a high-purity, chemically defined intermediate in the sphingolipid metabolic pathway. This compound is critical for research into ceramide biosynthesis, cellular signaling, and lipid metabolism studies. It is an essential standard and reagent for pharmaceutical R&D, academic research, and diagnostic assay development in the life sciences sector.

Application

• Biochemical Research: Used as a key intermediate and reference standard in studies of sphingolipid metabolism, ceramide synthesis, and related enzymatic pathways.
• Pharmaceutical Development: Serves as a critical building block and analytical standard in the research and development of therapeutics targeting metabolic disorders, cancer, and inflammatory diseases.
• Diagnostic Assays: Employed as a calibrant and control material in mass spectrometry-based lipidomic profiling and clinical diagnostic tests.
• Cell Biology Studies: Utilized to investigate the role of sphingolipids in cell signaling, apoptosis, and membrane biology.
• Enzyme Activity Analysis: Acts as a substrate or product in assays for enzymes like serine palmitoyltransferase and 3-ketosphinganine reductase.

Basic Information

Product Name	3-Keto Sphinganine (D18:0) (Hydrochloride)
CAS No.	35299-94-6
Molecular Formula	C18H38ClNO3
Molecular Weight	351.95 g/mol
Synonyms	3-Ketodihydrosphingosine Hydrochloride; D-erythro-3-Ketosphinganine Hydrochloride; 3-Oxosphinganine HCl; (2S,3R)-2-Amino-3-hydroxyoctadecan-1-one hydrochloride; Ketosphinganine (D18:0) HCl; 3-Ketosphinganine HCl; Sphinganine-3-one hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Keto Sphinganine (D18:0) (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic and easily oxidized nature, the product should be handled in a dry environment and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.