Description

3-Hydroxyglutaryl-Coenzyme A is a crucial biochemical intermediate in the metabolic pathway for cholesterol synthesis. This compound matters significantly for research and development in biochemistry, enzymology, and metabolic disease studies. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers focusing on lipid metabolism and enzyme inhibition studies.

Application

• Biochemical Research: Used as a key substrate in enzymatic studies of HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway.
• Pharmaceutical Development: Serves as a reference standard and intermediate in the development of novel cholesterol-lowering agents and metabolic regulators.
• Enzyme Kinetics: Essential for in vitro assays to determine enzyme activity, inhibition constants (Ki), and mechanistic studies of statin-class drugs.
• Diagnostic Reagents: Employed in the formulation of specialized diagnostic kits for assessing metabolic pathway functions.
• Academic Studies: Utilized in university and institutional labs for teaching and advanced research into isoprenoid and sterol biosynthesis.
• Metabolite Analysis: Acts as a calibration standard in LC-MS and other analytical techniques for quantifying metabolic intermediates in biological samples.

Basic Information

Product Name	3-Hydroxyglutaryl-Coenzyme A
CAS No.	35192-10-0
Molecular Formula	C27H44N7O20P3S
Molecular Weight	911.65 g/mol
Synonyms	HMG-CoA; (S)-3-Hydroxy-3-methylglutaryl-CoA; 3-Hydroxy-3-methylglutaryl coenzyme A; Hydroxymethylglutaryl-CoA; β-Hydroxy-β-methylglutaryl-CoA; Coenzyme A, S-[(3R)-3-hydroxy-3-methyl-1,5-dioxopentyl]-; 3-Hydroxy-3-methylglutaryl-Coenzyme A
EINECS	Contact for details

Quality Control

Our 3-Hydroxyglutaryl-Coenzyme A is produced under stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Biological Activity	Conforms to reference standard in enzymatic assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.