Description

(+)-Muscarine Chloride CAS NO 35119-35-8 is a high-purity, enantiomerically pure salt of the potent natural alkaloid muscarine. This compound is a critical reference standard and research chemical for studying the pharmacology of muscarinic acetylcholine receptors (mAChRs). It is essential for researchers and developers in the fields of neuroscience, pharmacology, and toxicology who require a reliable, well-characterized agonist for receptor binding assays, functional studies, and analytical method development.

Application

• Pharmacological Research: Primary tool for in vitro and ex vivo studies targeting muscarinic acetylcholine receptor subtypes (M1-M5).
• Neuroscience & Neuropharmacology: Used to investigate cholinergic signaling pathways, synaptic transmission, and the physiological roles of mAChRs in the central and peripheral nervous systems.
• Drug Discovery & Development: Serves as a key reference agonist for high-throughput screening (HTS) campaigns and for validating new compounds targeting the muscarinic receptor family.
• Toxicology & Safety Assessment: Employed as a precise analytical standard for the detection and quantification of muscarinic activity in various samples.
• Biochemical Assay Development: Critical for standardizing and calibrating functional assays such as calcium flux, IP3 accumulation, and GTPγS binding assays dependent on mAChR activation.
• Academic Research: Fundamental reagent for university and institutional labs exploring autonomic nervous system function, smooth muscle contraction, and glandular secretion.

Basic Information

Product Name	(+)-Muscarine Chloride
CAS No.	35119-35-8
Molecular Formula	C9H21ClNO2 +
Molecular Weight	210.72 g/mol (for cation, C9H21NO2+)
Synonyms	(+)-Muscarine chloride; L-(+)-Muscarine chloride; Muscarine chloride; (2S,4R,5S)-(4-Hydroxy-5-methyl-tetrahydrofuran-2-ylmethyl)-trimethyl-ammonium chloride; AGN-PC-0GNV6P; (2S,4R,5S)-4-Hydroxy-5-methyl-2-tetrahydrofuranylmethyltrimethylammonium chloride; FEMA 2759; Muscarine (chloride)
EINECS	Contact for details

Quality Control

Our (+)-Muscarine Chloride is produced under strict quality management protocols to ensure the highest standards of purity and enantiomeric integrity for research applications. Each batch is fully characterized using advanced analytical techniques including HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and residual solvent content is provided with every shipment to guarantee traceability and reproducibility for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Optical Rotation [α]D20	+ 24.0° to + 26.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.