Description

2-(Methylthio)-Adenosine 5'-Trihydrogen Diphosphate Trisodium is a chemically modified nucleotide analog of adenosine triphosphate (ATP), where a methylthio group replaces a hydrogen at the 2-position of the adenine ring. This modification is critical for its role as a potent and selective agonist for specific purinergic receptors, particularly the P2Y12 receptor, making it a valuable tool in biochemical and pharmacological research. It is primarily utilized by researchers in life sciences, pharmaceutical R&D, and diagnostic development for studying platelet aggregation, signal transduction pathways, and as a reference standard.

Application

• Biochemical Research: Used as a high-affinity agonist for P2Y12 receptors in studies of platelet activation and thrombosis mechanisms.
• Pharmaceutical Development: Serves as a key reference standard and pharmacological tool in the discovery and validation of novel antiplatelet and antithrombotic drugs.
• Signal Transduction Studies: Employed to investigate purinergic signaling pathways in cardiovascular, neurological, and immune system research.
• Enzyme Substrate/Analog: Acts as a substrate or inhibitor for various kinases, ATPases, and other nucleotide-binding enzymes.
• Diagnostic Reagents: A potential component in the formulation of specialized diagnostic kits for monitoring platelet function.

Basic Information

Product Name	2-(Methylthio)-Adenosine 5'-Trihydrogen Diphosphate Trisodium
CAS No.	34983-48-7
Molecular Formula	C11H14N5O12P3S · 3Na
Molecular Weight	623.16 g/mol (Free acid: 557.17 g/mol)
Synonyms	2-Methylthio-ATP trisodium salt; 2-MeS-ATP trisodium; Adenosine-5'-[trihydrogen diphosphate], 2-(methylthio)-, trisodium salt; 2-(Methylthio)adenosine 5'-triphosphate trisodium; P2Y12 receptor agonist; 2-MeSATP; 2-Methylthioadenosine triphosphate trisodium salt
EINECS	Contact for details

Quality Control

Our 2-(Methylthio)-Adenosine 5'-Trihydrogen Diphosphate Trisodium is produced under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and custom purity grades (e.g., >95%, >98%) are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
pH (1% Solution)	6.0 - 8.0
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.