Description

Z-Glu(Osu)-Obzl is a protected amino acid derivative widely used as a key building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates to construct complex peptides with precise stereochemistry. It is particularly valuable for the pharmaceutical, biotechnology, and life science research industries, where it facilitates the development of novel therapeutic agents and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A crucial reagent for the sequential coupling of glutamic acid residues while protecting the side-chain carboxyl group.
• Solution-Phase Peptide Synthesis: Used in classical solution methods for constructing peptide fragments, especially those containing glutamic acid.
• Pharmaceutical Intermediate: Serves as a key raw material in the research and production of peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Employed to introduce glutamic acid motifs or active ester functional groups into proteins, antibodies, or other biomolecules for labeling or cross-linking.
• Biochemical Research: Utilized in academic and industrial labs to study peptide structure-function relationships and enzyme-substrate interactions.
• Combinatorial Chemistry: A valuable building block for generating diverse peptide libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	Z-Glu(Osu)-Obzl
CAS No.	34897-67-1
Molecular Formula	C22H22N2O8
Molecular Weight	442.42 g/mol
Synonyms	Nα-Carbobenzoxy-L-glutamic acid α-benzyl ester N-hydroxysuccinimide ester; Z-L-Glu(OBzl)-OSu; Z-Glu(OBzl)-OSu; N-CBZ-L-glutamic acid 1-benzyl ester N-succinimidyl ester; Benzyl N-[(benzyloxy)carbonyl]-L-glutamate N-succinimidyl ester; CBZ-Glu(OBzl)-OSu; (S)-5-(Benzyloxy)-4-((((benzyloxy)carbonyl)amino)-5-oxopentanoic acid 2,5-dioxopyrrolidin-1-yl ester
EINECS	Contact for details

Quality Control

Our Z-Glu(Osu)-Obzl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.