Description

[2,3,4-Trihydroxy-5-(Phosphonooxymethyl)Oxolan-2-Yl]Methoxyphosphonic Acid is a high-purity, phosphorylated sugar derivative of significant biochemical interest. This compound serves as a critical intermediate and reference standard in the research and synthesis of nucleotide analogs and other bioactive molecules. It is essential for pharmaceutical R&D, academic research, and specialized chemical synthesis targeting enzyme inhibition and metabolic pathway studies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleotide-based therapeutics, including antiviral and anticancer agents.
• Biochemical Research: Used as a substrate, inhibitor, or reference standard in enzymatic studies, particularly those involving kinases, phosphatases, and metabolic enzymes.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical method development and quality control in pharmaceutical laboratories.
• Precursor for Prodrugs: Utilized in the development of phosphorylated prodrugs to enhance drug delivery and bioavailability.
• Chemical Biology Probes: Acts as a core structure for creating labeled probes to study cellular processes and signal transduction pathways.

Basic Information

Product Name	[2,3,4-Trihydroxy-5-(Phosphonooxymethyl)Oxolan-2-Yl]Methoxyphosphonic Acid
CAS No.	34693-23-7
Molecular Formula	C6H14O12P2
Molecular Weight	340.12 g/mol
Synonyms	Diphosphoric Acid Mono(1,2,3,4-Tetrahydroxybutyl) Ester; 1,2,3,4-Tetrahydroxybutyl Diphosphate; THB-DP; (2R,3S,4R)-2,3,4-Trihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]methyl Dihydrogen Phosphate; Tetrahydroxybutyl Diphosphate; Phosphorylated Tetritol; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our [2,3,4-Trihydroxy-5-(Phosphonooxymethyl)Oxolan-2-Yl]Methoxyphosphonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.