Description

Dimethyl Suberimidate Dihydrochloride is a bifunctional, homobifunctional imidoester crosslinking reagent. This compound is valued for its ability to form stable covalent bonds between primary amines under mild, physiological conditions, preserving the native charge of the target molecules. It is primarily utilized by researchers and manufacturers in the life sciences, particularly for protein-protein conjugation, antibody labeling, and the structural stabilization of biological assemblies. Its application is critical in biochemical research, diagnostic assay development, and biopharmaceutical processing.

Application

• Protein Crosslinking and Conjugation: Used as a homobifunctional crosslinker to conjugate antibodies, enzymes, and other proteins for immunoassays (ELISA, Western Blot) and diagnostic kits.
• Structural Biology Studies: Employed to stabilize protein complexes, virus particles, and membrane proteins for analysis via electron microscopy (EM) or X-ray crystallography.
• Affinity Chromatography: Serves as a spacer arm for immobilizing ligands (e.g., proteins, peptides) onto amine-functionalized solid supports like agarose or magnetic beads.
• Cell Surface Labeling: Facilitates the tagging of cell surface proteins and receptors for flow cytometry and fluorescence microscopy applications.
• Bioconjugation in Drug Delivery: Applied in the development of antibody-drug conjugates (ADCs) and other targeted therapeutic constructs.
• Material Science: Used to modify and functionalize amine-containing polymers or nanomaterials for biomedical and biosensor applications.

Basic Information

Product Name	Dimethyl Suberimidate Dihydrochloride
CAS No.	34490-86-3
Molecular Formula	C10H20N2O2 · 2HCl
Molecular Weight	281.20 g/mol (Free base: 200.28 g/mol)
Synonyms	Dimethyl Suberimidate Dihydrochloride; DMS · 2HCl; Suberimidic Acid, Dimethyl Ester, Dihydrochloride; Bis(methyl) Suberimidate Dihydrochloride; Dimethyl Octanedimidate Dihydrochloride; DMS; Crosslinker DMS; 1,8-Dimethyl Suberimidate Dihydrochloride
EINECS	Contact for details

Quality Control

Our Dimethyl Suberimidate Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay, impurity profile, and physical characteristics are provided and available upon request. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated). This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.