Description

Chelerythrine is a benzophenanthridine alkaloid known for its distinct biological activity and role as a potent, selective protein kinase C (PKC) inhibitor. This high-purity compound is essential for advanced biochemical and pharmacological research, providing a critical tool for studying cellular signaling pathways. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in drug discovery, cancer research, and the development of novel therapeutic agents.

Application

• Biochemical Research: As a selective inhibitor of protein kinase C (PKC), it is a fundamental tool for studying signal transduction, apoptosis, and cell proliferation mechanisms.
• Pharmaceutical R&D: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of anti-cancer and anti-inflammatory therapeutics.
• Academic Research: Used in university and institutional labs for investigating the role of PKC in various disease models, including neurological disorders and cardiovascular conditions.
• Cell Biology Studies: Applied in in vitro assays to modulate PKC activity and analyze its effects on gene expression and cellular responses.
• Natural Product Analysis: Acts as a marker compound for the identification and standardization of extracts from plants in the Papaveraceae family.

Basic Information

Product Name	Chelerythrine
CAS No.	34316-15-9
Molecular Formula	C21H18NO4+
Molecular Weight	348.37 g/mol
Synonyms	Chelerythrine chloride; Toddaline; 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium; Chelerythrine (cation); NSC 56346; DTXSID10872945; UNII-3G0285S8AP
EINECS	Contact for details

Quality Control

Our Chelerythrine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurities is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.