Description

Histrionicotoxin is a complex, naturally occurring alkaloid known for its potent biological activity as a non-competitive antagonist of nicotinic acetylcholine receptors. This compound is a critical research tool in neuroscience and pharmacology for studying receptor function and signal transduction pathways. It is primarily utilized by academic research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in neurobiological studies, drug discovery, and the development of novel therapeutic agents.

Application

• Neuroscience Research: A key pharmacological tool for investigating the structure and function of nicotinic acetylcholine receptors (nAChRs) in the central and peripheral nervous systems.
• Drug Discovery & Development: Used in high-throughput screening assays and target validation studies to identify and characterize new compounds for neurological disorders.
• Toxicology & Safety Pharmacology: Serves as a reference standard in studies examining the effects of neurotoxins and in the safety profiling of new chemical entities.
• Biochemical Studies: Employed in electrophysiology experiments and binding assays to understand ion channel kinetics and ligand-receptor interactions.
• Chemical Synthesis & Reference Standard: Used as a starting material or intermediate for the synthesis of analogs and as an analytical reference standard for quality control and method development.

Basic Information

Item	Detail
Product Name	Histrionicotoxin
CAS No.	34272-51-0
Molecular Formula	C19H31NO2
Molecular Weight	305.46 g/mol
Synonyms	Histrionicotoxin; HTX; (-)-Histrionicotoxin; (2S,6R,7S,8S)-8-Allyl-2-(3-methylbutyl)-1-azaspiro[5.5]undecan-7-ol; Perhydrohistrionicotoxin; Dendrobatid Toxin HTX; 1-Azaspiro[5.5]undecan-7-ol, 8-allyl-2-(3-methylbutyl)-, (2S,6R,7S,8S)-
EINECS	Contact for details

Quality Control

Our Histrionicotoxin is produced and handled under strict quality management protocols to ensure the highest standards of purity and consistency for research applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.