Description

Uridine, Periodate Oxidized is a chemically modified nucleoside derivative, specifically the product of periodate oxidation of uridine. This modification is critical for introducing reactive aldehyde groups, making it a valuable intermediate in bioconjugation and cross-linking chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors for applications such as oligonucleotide synthesis, probe labeling, and the development of targeted therapeutics.

Application

• Bioconjugation Reagent: Key intermediate for attaching biomolecules (e.g., proteins, peptides, antibodies) to other entities via its reactive aldehyde groups.
• Oligonucleotide Modification: Used in the synthesis and functionalization of DNA/RNA probes for diagnostics and research.
• Cross-linking Agent: Facilitates the creation of stable covalent bonds between biological macromolecules in assay development.
• Pharmaceutical Intermediate: Serves as a building block in the research and development of nucleoside-based antiviral or anticancer drugs.
• Diagnostic Kit Component: Employed in the manufacture of labeled probes for techniques like ELISA, FISH, and microarray analysis.
• Biomaterial Functionalization: Used to modify surfaces (e.g., chips, beads) with nucleosides for biosensor and microarray platforms.

Basic Information

Product Name	Uridine, Periodate Oxidized
CAS No.	34240-07-8
Molecular Formula	C9H10N2O7
Molecular Weight	258.19 g/mol
Synonyms	Periodate-Oxidized Uridine; 2',3'-Dialdehyde Uridine; Uridine 2',3'-Dialdehyde; cis-Uridine-2',3'-Dialdehyde; Oxidized Uridine; Uridine Dialdehyde; 1-((2R,3S,4R)-3,4-Dihydroxy-2,5-dioxotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our Uridine, Periodate Oxidized is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and bioconjugation applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.