Description

Nepsilon-Carbobenzoxy-Nalpha-Tosyl-L-Lysine is a protected derivative of the essential amino acid L-lysine, featuring orthogonal protecting groups on its alpha and epsilon amino functionalities. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, enabling precise control over molecular architecture. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for advanced drug discovery and development projects.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of lysine residues with orthogonal protection, allowing for sequential deprotection and selective functionalization.
• Pharmaceutical Research: Used in the development of peptide-based therapeutics, including hormone analogs, enzyme inhibitors, and targeted drug delivery systems.
• Bioconjugation Chemistry: Serves as a precursor for creating linkers and spacers in antibody-drug conjugates (ADCs) and other bioconjugates.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Fine Chemical Synthesis: Acts as a chiral synthon for the asymmetric synthesis of more complex organic molecules and natural product analogs.
• Biochemical Tool Development: Utilized in the preparation of modified peptides for studying protein-protein interactions, enzyme mechanisms, and cellular signaling pathways.

Basic Information

Product Name	Nepsilon-Carbobenzoxy-Nalpha-Tosyl-L-Lysine
CAS No.	34235-82-0
Molecular Formula	C22H28N2O6S
Molecular Weight	448.54 g/mol
Synonyms	Nε-Cbz-Nα-Tosyl-L-lysine; Z-Lys(Tos)-OH; Nα-Tosyl-Nε-carbobenzyloxy-L-lysine; (2S)-6-[[(Benzyloxy)carbonyl]amino]-2-[(4-methylphenyl)sulfonamido]hexanoic acid; Cbz-Lys(Tos)-OH; Nε-Z-Nα-Tos-L-lysine; N-Carbobenzoxy-N-tosyl-L-lysine; L-Lysine, N2-[(4-methylphenyl)sulfonyl]-N6-(phenylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Nepsilon-Carbobenzoxy-Nalpha-Tosyl-L-Lysine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.