Description

2'-o-Methyl-4-Thiouridine is a chemically modified nucleoside derivative, specifically a thiolated and methylated analog of uridine. This compound is of significant value in biochemical research and pharmaceutical development due to its role in studying RNA structure, function, and stability. It is primarily needed by research institutions, biotechnology companies, and pharmaceutical developers working on nucleic acid therapeutics, antisense technology, and RNA-based drug discovery.

Application

• Nucleic Acid Research: Used as a building block or probe in the study of RNA structure, folding, and intermolecular interactions.
• Antisense & siRNA Development: Serves as a modified nucleotide to enhance the stability and efficacy of therapeutic oligonucleotides against nuclease degradation.
• Bioconjugation & Labeling: The thiol group provides a reactive handle for site-specific conjugation with fluorescent dyes, affinity tags, or other molecules.
• Enzymology Studies: Employed as a substrate or inhibitor to investigate the activity and specificity of RNA-modifying enzymes, such as methyltransferases.
• Pharmaceutical Intermediates: Acts as a key synthetic intermediate in the production of novel nucleoside-based antiviral or anticancer agents.
• Diagnostic Probe Synthesis: Utilized in the creation of labeled probes for detecting specific RNA sequences in diagnostic assays.

Basic Information

Product Name	2'-o-Methyl-4-Thiouridine
CAS No.	34218-80-9
Molecular Formula	C10H14N2O6S
Molecular Weight	290.29 g/mol
Synonyms	4-Thio-2'-O-methyluridine; 2'-O-Methyl-4-thiouridine; 4-Thiouridine, 2'-O-methyl-; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl)pyrimidine-2,4-dione; 2'-O-Methyl-4-thio-uridine; 4-Thio-2'-OMe-uridine; s4Um; 2'-OMe-s4U
EINECS	Contact for details

Quality Control

Our 2'-o-Methyl-4-Thiouridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be kept tightly sealed in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.