Description

Chloroacetyl Coenzyme A is a key biochemical reagent and a crucial acyl-CoA derivative used in enzymatic and metabolic research. This compound serves as a vital substrate and intermediate for studying acyltransferase enzymes, fatty acid metabolism, and the biosynthesis of complex natural products. It is essential for researchers and manufacturers in the fields of pharmaceutical development, biochemical research, and enzymology, where precise control over acetylation and related metabolic pathways is required.

Application

• Enzymatic Research Substrate: Used as a critical acyl donor in studies of chloracetyltransferase and other acyl-CoA utilizing enzymes.
• Metabolic Pathway Analysis: Employed in investigating fatty acid metabolism, particularly the role of modified acyl-CoA compounds.
• Pharmaceutical Intermediate: Serves as a building block in the synthesis of more complex bioactive molecules and potential drug candidates.
• Biochemical Assay Development: Utilized in developing high-throughput screening assays for enzyme activity and inhibitor discovery.
• Biosynthesis Studies: Applied in research on the biosynthesis of polyketides and other natural products that incorporate chloroacetate units.
• Proteomics and Protein Labeling: Acts as a reagent for the site-specific modification of proteins and peptides.

Basic Information

Product Name	Chloroacetyl Coenzyme A
CAS No.	34201-15-5
Molecular Formula	C₂₃H₃₈ClN₇O₁₇P₃S
Molecular Weight	862.06 g/mol
Synonyms	Chloroacetyl-CoA; Coenzyme A, S-chloroacetyl-; S-Chloroacetylcoenzyme A; Chloroacetyl-CoA Lithium Salt; Chloroacetyl CoA; 2-Chloroacetyl-CoA; Acetyl-CoA, 2-chloro-; Acetylcoenzyme A, 2-chloro-
EINECS	Contact for details

Quality Control

Our Chloroacetyl Coenzyme A is produced under controlled conditions to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic identification. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Biological Activity	Functional in standard enzyme assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.