Description

Clivorine is a naturally occurring pyrrolizidine alkaloid (PA) isolated from specific plant species, recognized by the CAS registry number 33979-15-6. This compound is of significant interest in biochemical and pharmaceutical research due to its potent biological activity and role as a model compound for studying hepatotoxicity. It serves as a critical reference standard and intermediate for researchers and developers in the life sciences sector. Key industries that utilize this high-purity compound include pharmaceutical R&D, toxicology studies, and academic research institutions focused on natural product chemistry.

Application

• Pharmaceutical Reference Standard: Used as a certified analytical standard for quality control and method validation in drug development and safety testing.
• Toxicological Research: Serves as a key compound in studies investigating the mechanisms of hepatotoxicity and genotoxicity associated with pyrrolizidine alkaloids.
• Biochemical Pathway Analysis: Employed in research to understand metabolic activation, detoxification pathways, and DNA adduct formation.
• Natural Product Isolation & Synthesis: Acts as a benchmark for the extraction, purification, and synthetic modification of related alkaloids.
• Herbal Medicine Safety Assessment: Essential for screening and quantifying PAs in botanical ingredients, supplements, and traditional medicines to ensure consumer safety.
• Academic & Institutional Research: Provides a high-purity material for university and government lab studies in chemistry, pharmacology, and environmental science.

Basic Information

Product Name	Clivorine
CAS No.	33979-15-6
Molecular Formula	C20H27NO7
Molecular Weight	393.43 g/mol
Synonyms	Clivorine; (-)-Clivorine; (13S,14R)-13-[(2-Methylbutanoyl)oxy]-12,14-dihydroxy-13,14-dihydrosenecionan-11,16-dione; 12-Hydroxysenecionan-11,16-dione, 13-[(2-methyl-1-oxobutoxy)oxy]-, (13S,14R)-; Lasiocarpine N-oxide isomer; A pyrrolizidine alkaloid from Ligularia species.
EINECS	Contact for details

Quality Control

Our Clivorine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods (NMR, MS) for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results. We support compliance with relevant research and quality guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.