Description

Atropine Hydrochloride is a high-purity, crystalline salt form of the classic anticholinergic alkaloid, atropine. This compound is essential for its potent parasympatholytic activity, serving as a critical active pharmaceutical ingredient (API) and a vital research tool. It is primarily required by the pharmaceutical industry for the formulation of injectable solutions, ophthalmic preparations, and as a reference standard in analytical laboratories.

Application

• Pharmaceutical API: Core ingredient in injectable formulations used as a pre-anesthetic to reduce secretions and to treat bradycardia.
• Ophthalmic Solutions: Used in eye drops for pupil dilation (mydriasis) and cycloplegia during eye examinations and surgeries.
• Antidote Production: A key component in antidotes for organophosphate and carbamate pesticide or nerve agent poisoning.
• Biochemical Research: A standard muscarinic acetylcholine receptor (mAChR) antagonist in pharmacological and neurological studies.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and assay calibration in pharmaceutical analysis.
• Veterinary Medicine: Employed in veterinary practices for similar therapeutic purposes as in human medicine.

Basic Information

Product Name	Atropine Hydrochloride
CAS No.	33952-38-4
Molecular Formula	C17H23NO3·HCl
Molecular Weight	325.83 g/mol
Synonyms	Atropine HCl; Atropine Hydrochloride Monohydrate; dl-Hyoscyamine Hydrochloride; Tropine Tropate Hydrochloride; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate hydrochloride; (±)-Hyoscyamine Hydrochloride; Atropini Hydrochloridum; Atropinum Sulfuricum
EINECS	Contact for details

Quality Control

Our Atropine Hydrochloride is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to meet high-purity standards suitable for pharmaceutical applications, including identification, assay, impurity profiling, and residual solvent analysis. Certificates of Analysis (COA) compliant with USP, EP, and in-house specifications are provided with each batch to ensure traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
pH (5% solution)	4.0 - 6.0
Specific Rotation	-0.10° to +0.10°
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.