Description

Demethyl Tetrandrine is a key bisbenzylisoquinoline alkaloid derivative, valued for its distinct pharmacological profile compared to its parent compound, Tetrandrine. This product is essential for researchers and developers in the pharmaceutical and life sciences sectors seeking to explore novel therapeutic pathways. Its primary applications are in advanced pharmaceutical research, particularly in the study of anti-inflammatory, anti-fibrotic, and potential anti-cancer mechanisms.

Application

• Pharmaceutical Reference Standard: Used as a high-purity standard for analytical method development, validation, and quality control in drug discovery and development.
• Biochemical Research: A critical tool for studying calcium channel blockade, autophagy modulation, and other cellular signaling pathways in vitro.
• Preclinical Studies: Employed in animal models to investigate its efficacy and pharmacokinetics for conditions like pulmonary fibrosis, arthritis, and liver diseases.
• Natural Product Derivative Synthesis: Serves as a sophisticated intermediate or starting material for the semi-synthesis of novel analogs with optimized biological activity.
• Mechanism of Action (MoA) Studies: Utilized to elucidate specific molecular targets and interactions, contributing to the understanding of complex disease biology.

Basic Information

Product Name	Demethyl Tetrandrine
CAS No.	33889-68-8
Molecular Formula	C37H40N2O6
Molecular Weight	608.73 g/mol
Synonyms	N-Desmethyltetrandrine; Fangchinoline; 6',7',12-Trimethoxy-2,2'-dimethylberbaman; (1β)-6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman; Hanfangchin A; Tetrandrine Monodemethylated; O-Demethyltetrandrine; Demethyltetrandrine
EINECS	Contact for details

Quality Control

Our Demethyl Tetrandrine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and MS for identification, and residual solvent analysis, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.