Description

8-Hydroxyethylaminoadenosine 3',5'-Monophosphate is a chemically modified derivative of cyclic adenosine monophosphate (cAMP), a fundamental secondary messenger in cellular signaling. This compound matters for researchers and developers as it provides a more stable and cell-permeable analog for probing and modulating intracellular cAMP-dependent pathways. It is primarily needed by the pharmaceutical, biotechnology, and life science research sectors for applications in drug discovery, biochemical research, and the development of novel therapeutic agents targeting signal transduction.

Application

• Biochemical Research: Used as a stable, cell-permeable analog of cAMP to study intracellular signaling cascades, protein kinase A (PKA) activation, and gene expression regulation.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the synthesis and screening of novel therapeutics targeting cardiovascular, neurological, and metabolic disorders.
• Cell Biology Studies: Employed to investigate the role of cAMP in cell proliferation, differentiation, and apoptosis in various cell culture models.
• Enzyme Assays: Acts as a substrate or modulator in assays for phosphodiesterases (PDEs) and other enzymes involved in nucleotide metabolism.
• Diagnostic Reagent Manufacturing: Utilized in the formulation of high-purity reagents for diagnostic kits and research assays.
• Academic Research: A critical tool for universities and research institutes exploring fundamental biological processes and signal transduction mechanisms.

Basic Information

Product Name	8-Hydroxyethylaminoadenosine 3',5'-Monophosphate
CAS No.	33823-17-5
Molecular Formula	C₁₇H₂₃N₆O₈P
Molecular Weight	470.38 g/mol
Synonyms	8-(2-Hydroxyethylamino)adenosine 3',5'-cyclic monophosphate; 8-HEA-cAMP; 8-(2-Hydroxyethylamino)-cAMP; N⁶-(2-Hydroxyethyl)-3',5'-cyclic adenosine monophosphate; 8-(2-Hydroxyethylamino) cyclic AMP; cAMP, 8-(2-hydroxyethylamino)-; 8-Hydroxyethylamino-cAMP; 8-HEA-cyclic AMP
EINECS	Contact for details

Quality Control

Our 8-Hydroxyethylaminoadenosine 3',5'-Monophosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.