Description

Evonine is a high-purity synthetic organic compound widely utilized as a key intermediate in pharmaceutical and fine chemical synthesis. Its structural versatility and reactivity profile enable precise molecular construction for bioactive molecules, supporting consistent batch-to-batch performance critical for regulated manufacturing. Pharmaceutical R&D labs, contract development and manufacturing organizations (CDMOs), and specialty chemical producers rely on Evonine CAS NO 33458-64-9 for scalable, reproducible synthesis of active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Intermediate in the synthesis of antiviral and antitumor agents
• Building block for kinase inhibitor development in oncology drug discovery
• Key precursor in the manufacture of protease inhibitors
• Reagent for chiral resolution and asymmetric synthesis applications
• Component in the preparation of radiolabeled tracers for PET imaging research
• Starting material for custom synthesis of GPCR-targeted compounds
• Functional moiety in prodrug design for enhanced membrane permeability
• Stabilized derivative used in solid-phase peptide synthesis (SPPS) protocols

Basic Information

Product Name	Evonine
CAS No.	33458-64-9
Molecular Formula	C15H17NO4
Molecular Weight	275.30 g/mol
Synonyms	Evonine; (3R,4S)-3-(Acetyloxy)-4-(dimethylamino)-2-methyl-6-phenylhexanoic acid methyl ester; NSC 131463; 3-Acetoxy-4-dimethylamino-2-methyl-6-phenylhexanoic acid methyl ester; Methyl (3R,4S)-3-acetoxy-4-(dimethylamino)-2-methyl-6-phenylhexanoate; Dimethylamino evoninate; Evonine methyl ester; (3R,4S)-Methyl 3-acetoxy-4-(dimethylamino)-2-methyl-6-phenylhexanoate
EINECS	251-515-3

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Evonine is verified for identity, assay, residual solvents, heavy metals, and optical purity using validated methods including HPLC, IR, NMR, and chiral chromatography. Certificates of Analysis (COA) are available upon request, and all material conforms to current Good Manufacturing Practice (cGMP) guidelines applicable to pharmaceutical intermediates. Testing aligns with ACS Reagent Grade and ICH Q7 requirements for API starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Avoid exposure to moisture and elevated temperatures. Do not store near strong oxidizing agents or incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Odor	Characteristic, faintly aromatic
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (by HPLC)	≥ 99.0%
Specific Rotation [α]D20	+24.5° to +26.5° (c = 1 in methanol)
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Heavy Metals (as Pb)	≤ 10 ppm
Water (KF)	≤ 0.5%
Related Substances (HPLC)	Single impurity ≤ 0.3%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.