Description

Adenosine, Adenylyl-(3'->5')-, Mono(Hydrogen Phosphonate) (Ester) is a chemically modified nucleotide analog of significant interest in biochemical research and pharmaceutical development. This compound serves as a crucial building block and research tool for studying nucleic acid interactions, enzyme mechanisms, and signal transduction pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on nucleotide-based therapeutics and molecular biology.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for kinases, phosphatases, and polymerases involved in nucleotide metabolism.
• Pharmaceutical R&D: Serves as a key intermediate or precursor in the synthesis of novel nucleotide-based drugs, including potential antiviral or anticancer agents.
• Molecular Biology: Employed in the study of RNA structure, function, and processing due to its modified phosphonate linkage, which can mimic or resist cleavage.
• Probe Development: Utilized in the creation of labeled probes or affinity tags for investigating protein-nucleic acid interactions and cellular signaling pathways.
• Enzyme Mechanism Studies: Acts as a tool compound to elucidate the catalytic mechanisms of enzymes that process adenosine derivatives or phosphoester bonds.

Basic Information

Product Name	Adenosine, Adenylyl-(3'->5')-, Mono(Hydrogen Phosphonate) (Ester)
CAS No.	33009-07-3
Molecular Formula	C20H25N10O12P
Molecular Weight	628.45 g/mol
Synonyms	Adenylyl-(3'-5')-adenosine monophosphonate; 3'-5'-Adenylyl adenosine monophosphonate; ApA phosphonate; P1,P2-Di(adenosin-5'-yl) triphosphonate; Adenosine(5')triphospho(5')adenosine monoanhydride phosphonate; 5'-Adenylyl-(3'-5')-adenosine monophosphonate; Dinucleoside monophosphonate; 3',5'-ADP analog
EINECS	Contact for details

Quality Control

Our Adenosine, Adenylyl-(3'->5')-, Mono(Hydrogen Phosphonate) (Ester) is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.