Description

n-(Trimethylsilyl)-2'-O,5'-o-Bis(Trimethylsilyl)Adenosine 3'-[Phosphoric Acid Bis(Trimethylsilyl)] Ester CAS NO 32653-17-1 is a highly protected adenosine derivative, extensively silylated to provide exceptional stability and solubility for advanced synthetic manipulations. This compound is a critical intermediate in the synthesis of complex nucleosides, nucleotides, and oligonucleotide analogs, enabling precise chemical modifications that are essential for pharmaceutical and biochemical research. It is primarily utilized by research institutions and pharmaceutical developers working on antiviral agents, mRNA therapeutics, and novel diagnostic probes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of modified nucleoside analogs used in antiviral and anticancer drug development.
• Oligonucleotide Synthesis: Serves as a protected phosphoramidite precursor for solid-phase synthesis of modified RNA and DNA strands.
• Biochemical Research: Used in studies of enzyme mechanisms, particularly those involving kinases, polymerases, and other nucleotide-processing enzymes.
• Pro-drug Development: Facilitates the creation of lipophilic pro-drug forms of nucleoside-based therapeutics to enhance cellular uptake.
• Labeled Compound Synthesis: Intermediate for introducing isotopic labels (e.g., 13C, 15N, 32P) into nucleosides for metabolic tracing and imaging studies.
• Material Science: Potential use in creating nucleotide-functionalized surfaces or polymers for biosensor applications.

Basic Information

Product Name	n-(Trimethylsilyl)-2'-O,5'-o-Bis(Trimethylsilyl)Adenosine 3'-[Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	32653-17-1
Molecular Formula	C27H58N5O7P Si5
Molecular Weight	756.28 g/mol
Synonyms	Adenosine, N-[trimethylsilyl]-2',5'-bis-O-(trimethylsilyl)-, 3'-[bis(trimethylsilyl) phosphate]; 3'-O-Bis(trimethylsilyl)phosphoryl-N,2',5'-tri-O-trimethylsilyladenosine; Fully Silylated Adenosine 3'-Phosphate; N,2',5'-Tri-O-trimethylsilyladenosine 3'-(bis(trimethylsilyl) phosphate); TMS-Adenosine Derivative; Protected Adenosine 3'-Phosphate Ester; CAS 32653-17-1
EINECS	Contact for details

Quality Control

Our production of this advanced synthetic intermediate adheres to stringent quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and development documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in common organic solvents (e.g., THF, acetonitrile, dichloromethane)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.