Description

(-)-Di-p-Toluoyl-L-Tartaric Acid is a high-purity chiral resolving agent derived from L-tartaric acid. This compound is critically important for its ability to separate enantiomers of racemic mixtures, particularly amines and amino alcohols, through diastereomeric salt formation. It is an essential tool for pharmaceutical R&D, fine chemical synthesis, and the production of single-enantiomer active pharmaceutical ingredients (APIs).

Application

• Chiral Resolution of Racemic Amines: Primary application for separating enantiomers in pharmaceutical intermediates and fine chemicals.
• Pharmaceutical Synthesis: Key resolving agent in the production of enantiomerically pure APIs and drug candidates.
• Asymmetric Catalyst Preparation: Used in the synthesis of chiral ligands and organocatalysts.
• Analytical Chemistry: Serves as a chiral selector or derivatizing agent in HPLC and other chromatographic methods for enantiomeric purity analysis.
• Fine Chemical Manufacturing: Employed in the synthesis of specialty chemicals requiring high optical purity.
• Academic & Industrial Research: A standard reagent for method development and stereochemistry studies in organic chemistry.

Basic Information

Product Name	(-)-Di-p-Toluoyl-L-Tartaric Acid
CAS No.	32634-66-5
Molecular Formula	C20H18O8
Molecular Weight	386.35 g/mol
Synonyms	(-)-DTTA; L-(-)-Di-p-Toluoyltartaric Acid; (2R,3R)-2,3-Bis(4-methylbenzoyloxy)succinic Acid; (2R,3R)-O,O'-Di-p-toluoyl-L-tartaric Acid; (-)-O,O'-Di-p-Toluoyl-L-Tartaric Acid; L-Di-p-Toluoyltartaric Acid; (2R,3R)-2,3-Di(4-methylbenzoyloxy)butanedioic Acid
EINECS	251-125-7

Quality Control

Our (-)-Di-p-Toluoyl-L-Tartaric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling, to ensure it meets the stringent requirements for chiral resolution applications. Certificates of Analysis (COA) detailing specific purity, optical rotation, and chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0%
Specific Optical Rotation [α]20/D	-130° to -140° (c=1 in Acetone)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.