Description

Cholic Acid, [Carboxy-14C] is a carbon-14 radiolabeled derivative of the primary bile acid, cholic acid, specifically labeled at the carboxyl group. This compound is an essential tool for conducting detailed metabolic and pharmacokinetic studies, enabling precise tracking of the acid's absorption, distribution, metabolism, and excretion (ADME) in biological systems. It is critically needed by researchers and scientists in the pharmaceutical, biotechnology, and academic sectors for advanced tracer studies, drug development research, and investigations into bile acid physiology and related disorders.

Application

• ADME (Absorption, Distribution, Metabolism, Excretion) Studies: Used as a radiotracer to investigate the pharmacokinetic profile and metabolic pathways of cholic acid and related compounds in preclinical research.
• Drug Development & Discovery: Facilitates the study of drug-bile acid interactions, hepatobiliary transport mechanisms, and the development of therapies for cholestatic liver diseases.
• Biochemical Pathway Analysis: Enables the elucidation of bile acid synthesis, conjugation, and enterohepatic circulation in metabolic research.
• In Vitro & In Vivo Tracer Studies: Serves as a critical reagent for labeling experiments in cell cultures and animal models to study bile acid function and homeostasis.
• Environmental & Agricultural Research: Can be applied in specialized studies tracking the environmental fate of steroid-based compounds.

Basic Information

Product Name	Cholic Acid, [Carboxy-14C]
CAS No.	32447-38-4
Molecular Formula	C₂₄H₄₀O₅ * (¹⁴C)
Molecular Weight	~409.6 g/mol (exact mass depends on specific activity)
Synonyms	3α,7α,12α-Trihydroxy-5β-cholan-24-oic-24-¹⁴C acid; (24-¹⁴C)Cholic Acid; ¹⁴C-Cholic Acid; Cholalic-24-¹⁴C Acid; 5β-Cholan-24-oic-24-¹⁴C acid, 3α,7α,12α-trihydroxy-, (3α,5β,7α,12α)-; Radiolabeled Cholic Acid
EINECS	Contact for details

Quality Control

Every batch of Cholic Acid, [Carboxy-14C] is manufactured and analyzed under strict quality systems to ensure high chemical and radiochemical purity, specific activity, and stability. Our quality commitment includes rigorous analytical testing via HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, specific activity (mCi/mmol or GBq/mmol), radiochemical identity, and solvent composition. We adhere to relevant GLP (Good Laboratory Practice) standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the vial sealed under an inert atmosphere. Follow all applicable laboratory safety and radiation safety protocols for handling and disposal.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC, MS)	Conforms to reference standard
Chemical Purity (HPLC)	≥ 95%
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (1.85-2.22 GBq/mmol) [Custom ranges available]
Solvent (if supplied in solution)	Ethanol, Methanol, or as specified
Concentration (if supplied in solution)	1.0 mCi/mL (37 MBq/mL) or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.