Description

Pglu-His-Oh CAS NO 32159-22-1 is a high-purity, protected dipeptide derivative consisting of pyroglutamic acid and histidine. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise construction of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediates: Key raw material for the synthesis of therapeutic peptides targeting metabolic disorders, neurological conditions, and hormonal regulation.
• Bioconjugation & Probe Development: Used in the creation of labeled peptides for imaging, diagnostic assays, and targeted drug delivery systems.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies, receptor-ligand interaction assays, and structure-activity relationship (SAR) research.
• Cosmeceutical Actives: Incorporated into the synthesis of bioactive peptides for anti-aging, skin repair, and moisturizing cosmetic formulations.
• Peptide Library Construction: A fundamental component in combinatorial chemistry for generating diverse peptide libraries for high-throughput screening.

Basic Information

Product Name	Pglu-His-Oh
CAS No.	32159-22-1
Molecular Formula	C11H15N3O4
Molecular Weight	253.26 g/mol
Synonyms	L-Pyroglutamyl-L-histidine; Pyroglutamylhistidine; 5-Oxo-L-prolyl-L-histidine; Pglu-His; H-Pyr-His-OH; Pyr-His; (S)-2-((S)-5-Oxopyrrolidine-2-carboxamido)-3-(1H-imidazol-4-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Pglu-His-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral purity analysis to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Specific Rotation	-40° to -50° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.