Description

8-Azidoadenosine 3':5'-Cyclic Monophosphate is a chemically modified, photoactivatable analog of the universal second messenger cAMP. This compound matters as a critical biochemical tool for studying cAMP-dependent signaling pathways through targeted cross-linking and irreversible activation of protein kinase A (PKA). It is primarily needed by researchers in pharmaceutical R&D, biochemistry, and molecular biology for applications in signal transduction studies, photaffinity labeling, and the development of novel therapeutic strategies.

Application

• Photaffinity Labeling Probe: Used to irreversibly bind and identify cAMP-binding proteins and receptors in complex biological systems.
• Protein Kinase A (PKA) Activation: Serves as a potent, light-dependent activator for studying cAMP/PKA signaling cascades in cell biology.
• Biochemical Research Reagent: Essential for in vitro studies of nucleotide-mediated processes, enzyme kinetics, and allosteric regulation.
• Signal Transduction Studies: Enables precise spatial and temporal control over cAMP signaling in live cells and tissue samples.
• Drug Discovery Target Validation: Utilized in high-throughput screening and mechanism-of-action studies for diseases involving dysregulated cAMP pathways.
• Proteomics and Structural Biology: Aids in mapping protein interaction sites and understanding the structural basis of cAMP-mediated regulation.

Basic Information

Product Name	8-Azidoadenosine 3':5'-Cyclic Monophosphate
CAS No.	31966-52-6
Molecular Formula	C11H12N8O6P
Molecular Weight	383.24 g/mol
Synonyms	8-Azido-cAMP; 8-N3-cAMP; 8-Azidoadenosine cyclic 3',5'-(hydrogen phosphate); 8-Azido-cyclic adenosine monophosphate; 8-Azido-3',5'-cyclic AMP; 8-Azido-adenosine-3',5'-cyclic monophosphate; cAMP, 8-azido-; 8-Azidoadenylyl cyclase activator
EINECS	Contact for details

Quality Control

Our 8-Azidoadenosine 3':5'-Cyclic Monophosphate is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.