Description

H-Ala-Pna Hcl CAS NO 31796-55-1 is a protected dipeptide building block, specifically L-Alanine coupled to p-nitroaniline (Pna) with a hydrochloride salt. This compound is a critical intermediate in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains with high fidelity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the sequential assembly of custom peptides in drug discovery and research.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) and therapeutic candidates.
• Biochemical Research: Employed in the study of enzyme-substrate interactions, protease activity, and the synthesis of enzyme inhibitors.
• Combinatorial Chemistry Libraries: Serves as a key component for generating diverse peptide libraries for high-throughput screening.
• Academic Research: Used in university and institutional labs for teaching advanced organic synthesis techniques and peptide chemistry.
• Production of Custom Peptides: Essential for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke peptide synthesis services.

Basic Information

Product Name	H-Ala-Pna Hcl
CAS No.	31796-55-1
Molecular Formula	C9H12N3O3 • HCl
Molecular Weight	247.67 g/mol (Free base: 210.21 g/mol)
Synonyms	H-Ala-pNA HCl; L-Alanine 4-nitroanilide hydrochloride; N-(4-Nitrophenyl)-L-alaninamide hydrochloride; Ala-pNA•HCl; Alanine p-nitroanilide hydrochloride; L-Ala-pNA HCl; Peptide Synthesis Building Block A001; 4-Nitroanilide of L-alanine hydrochloride
EINECS	Contact for details

Quality Control

Our H-Ala-Pna Hcl is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: +20° to +30° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.