Description

Guanosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is a chemically modified, non-hydrolyzable analog of cyclic GMP (cGMP) that acts as a potent and selective competitive inhibitor of cGMP-dependent protein kinase (PKG). This compound is a critical research tool for elucidating the role of the cGMP/PKG signaling pathway in cellular processes such as smooth muscle relaxation, platelet aggregation, and neuronal signaling. It is essential for researchers and developers in pharmaceutical discovery, biochemical research, and diagnostic assay development who require high-purity, biologically active probes to study intracellular signal transduction.

Application

• Biochemical Research: As a selective PKG inhibitor to study cGMP-mediated signal transduction pathways in cell-free systems and cellular models.
• Cardiovascular & Smooth Muscle Physiology: Investigation of vascular tone, blood pressure regulation, and bronchodilation mechanisms.
• Neuroscience Research: Probing the role of cGMP/PKG in synaptic plasticity, memory formation, and neuronal excitability.
• Platelet Function Studies: Research into mechanisms of platelet inhibition and aggregation for anti-thrombotic drug discovery.
• Pharmaceutical Screening: Used as a reference standard and tool compound in high-throughput screening (HTS) assays for drug candidates targeting the PKG pathway.
• Diagnostic Development: A key component in the development of ELISA and other immunoassays for quantifying cGMP levels or PKG activity.

Basic Information

Product Name	Guanosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt
CAS No.	31357-06-9
Molecular Formula	C10H11N5Na2O10PS2 · xH2O
Molecular Weight	Contact for details
Synonyms	Rp-cGMPS sodium salt; Rp-Guanosine 3',5'-cyclic monophosphorothioate sodium salt; Rp-8-Br-cGMPS (related analog); Rp-isomer of cyclic guanosine monophosphorothioate; PKG Inhibitor Rp-8-pCPT-cGMPS (related analog); Rp-cGMP-S; Sodium (Rp)-guanosine-3',5'-cyclic phosphorothioate
EINECS	Contact for details

Quality Control

Our Guanosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive life science research. Certificates of Analysis (COA) detailing purity, water content, and spectroscopic data are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere. Allow the vial to warm to room temperature in a dry atmosphere before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Biological Activity	Potent inhibition of PKG
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.