Description

8-Br-cGMP is a cell-permeable, phosphodiesterase-resistant analog of cyclic guanosine monophosphate (cGMP) that acts as a potent activator of cGMP-dependent protein kinase (PKG). This compound is a crucial pharmacological tool for studying intracellular signaling pathways, particularly those mediated by nitric oxide and natriuretic peptides. It is essential for researchers and developers in the fields of cardiovascular physiology, neurobiology, and smooth muscle function, providing a stable means to probe PKG-mediated effects in cellular and tissue models.

Application

• Biochemical Research: As a stable and membrane-permeable activator of Protein Kinase G (PKG) for investigating cGMP signaling cascades.
• Cardiovascular Studies: Used to model and study vasodilation, platelet aggregation inhibition, and cardiac contractility mechanisms.
• Neuroscience: Employed in research on synaptic plasticity, neurotransmitter release, and long-term potentiation (LTP) where cGMP pathways are involved.
• Smooth Muscle Physiology: A key tool for examining relaxation responses in vascular, bronchial, and gastrointestinal smooth muscle tissues.
• Drug Discovery: Serves as a reference compound and positive control in high-throughput screening for novel PKG-targeting therapeutics.
• Cellular Signaling: Used to elucidate pathways related to cell proliferation, apoptosis, and ion channel regulation.

Basic Information

Item	Detail
Product Name	8-Br-cGMP
CAS No.	31356-94-2
Molecular Formula	C10H11BrN5O7P
Molecular Weight	424.10 g/mol
Synonyms	8-Bromoguanosine 3',5'-cyclic monophosphate; 8-Bromo-cyclic GMP; 8-Br-cyclic GMP; 8-Bromocyclic GMP; 8-Bromo-cGMP; Guanosine 3',5'-cyclic monophosphate, 8-bromo-; 8-Br-cGMP sodium salt (common salt form); 8-Bromo-3',5'-cyclic guanosine monophosphate
EINECS	Contact for details

Quality Control

Our 8-Br-cGMP is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.