Description

Z-D-Nle-Onp CAS NO 31062-20-1 is a specialized, optically active amino acid derivative widely used as a key building block in peptide synthesis. Its primary value lies in providing a protected norleucine residue with orthogonal protecting groups, enabling precise and complex peptide chain assembly. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic peptides, peptide hormones, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the controlled, sequential addition of norleucine in automated and manual peptide synthesis protocols.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Labeling: Serves as a precursor for creating modified peptides with specific tags, probes, or linkers for diagnostic and research applications.
• Biochemical Research: Employed in academic and industrial laboratories to study protein structure-function relationships, enzyme substrates, and receptor ligands.
• Production of Custom Peptides: A fundamental raw material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke peptide services.
• Agrochemical Research: Potential use in the synthesis of bioactive peptide analogs for crop protection and agricultural science.

Basic Information

Product Name	Z-D-Nle-Onp
CAS No.	31062-20-1
Molecular Formula	C20H22N2O6
Molecular Weight	386.40 g/mol
Synonyms	Nα-Z-D-Norleucine 4-Nitrophenyl Ester; Z-D-Nle-ONp; Z-D-Norleucine p-Nitrophenyl Ester; (R)-2-(((Benzyloxy)carbonyl)amino)-6-(4-nitrophenoxy)-6-oxohexanoic acid; D-Norleucine, N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester; CBZ-D-Norleucine ONP Ester; Benzyloxycarbonyl-D-norleucine p-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our Z-D-Nle-Onp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the exacting standards required for advanced peptide synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.