Description

Adenosine 5'-Phospho-2-Methylimidazolide is a chemically activated nucleotide derivative, serving as a key intermediate in the synthesis of nucleoside polyphosphates and oligonucleotides. Its primary value lies in its role as a phosphorylating agent, enabling the efficient and controlled formation of phosphodiester bonds under mild conditions. This makes it an essential reagent for researchers and manufacturers in pharmaceutical development, molecular biology, and synthetic biochemistry, particularly for creating nucleotide analogs and labeled compounds.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Oligonucleotide Synthesis: Used as a building block or activating agent in the preparation of modified DNA and RNA strands for research and therapeutic applications.
• Bioconjugation: Facilitates the site-specific labeling of biomolecules (e.g., proteins, peptides) with nucleotide tags or fluorophores.
• Enzymology Studies: Serves as a substrate analog or inhibitor in studies of kinase, polymerase, and other nucleotide-processing enzymes.
• Chemical Biology Tool: Enables the synthesis of dinucleoside polyphosphates (e.g., ApnA analogs) used as signaling molecules.
• Diagnostic Reagent Manufacturing: Employed in the production of components for diagnostic kits and assays.

Basic Information

Product Name	Adenosine 5'-Phospho-2-Methylimidazolide
CAS No.	31008-65-8
Molecular Formula	C14H18N7O6P
Molecular Weight	435.32 g/mol
Synonyms	2-Methylimidazolide of Adenosine 5'-Monophosphate; AMP-Imidazolide; Adenosine 5'-Monophospho-2-methylimidazolide; 2-Methyl-1H-imidazol-1-yl Adenosine 5'-(Dihydrogen Phosphate); 5'-AMP-2-Methylimidazolide; Adenosine-5'-monophosphorimidazolidate; P1-(Adenosine-5')-P2-(2-methylimidazol-1-yl) diphosphate
EINECS	Contact for details

Quality Control

Our Adenosine 5'-Phospho-2-Methylimidazolide is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic identification (NMR, IR). Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake. Use in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.