Description

Isocolchicine is a bioactive alkaloid derivative, structurally related to colchicine, known for its specific biological activity. This compound is valued in research and development for its role as a key intermediate and reference standard in pharmacological studies. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for investigating tubulin binding, anti-inflammatory mechanisms, and developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of more complex colchicine analogs and novel drug candidates.
• Biochemical Research: Used as a reference standard and tool compound in studies of microtubule dynamics, cell cycle inhibition, and anti-inflammatory pathways.
• Analytical Standard: Employed in HPLC, LC-MS, and other analytical methods for method development, validation, and quality control of related substances.
• Academic & Discovery Research: Facilitates basic research in medicinal chemistry and pharmacology for exploring new structure-activity relationships.

Basic Information

Product Name	Isocolchicine
CAS No.	30771-10-9
Molecular Formula	C22H25NO6
Molecular Weight	399.44 g/mol
Synonyms	N-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide; Colchiceine Amide; Isocolchiceine; Isocolchicine; 3-Demethylcolchicine; N-Acetylcolchiceinamide; Deacetylcolchicine Amide; NSC 406042
EINECS	Contact for details

Quality Control

Our Isocolchicine is produced and tested under a rigorous quality management system. Each batch is analyzed to ensure high purity and consistency, with specifications aligned with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.