Description

Di(n-Succinimidyl) Malonate is a high-purity, bifunctional N-hydroxysuccinimide (NHS) ester crosslinker used for the efficient conjugation of biomolecules. This compound is critical for creating stable amide bonds between primary amines, enabling the precise construction of protein-protein conjugates, antibody-drug conjugates (ADCs), and peptide modifications. It is an essential reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and diagnostic assay production who require reliable, high-yield coupling chemistry.

Application

• Primary reagent for the synthesis of antibody-drug conjugates (ADCs) and other biopharmaceuticals.
• Crosslinking agent for protein-protein conjugation and immobilization on solid supports.
• Key intermediate in peptide synthesis and the modification of peptides with labels or functional groups.
• Preparation of fluorescent or enzyme-labeled probes for diagnostic and research applications.
• Surface functionalization of nanoparticles and polymers for targeted drug delivery systems.
• Tool compound in biochemical research for studying protein interactions and signaling pathways.

Basic Information

Product Name	Di(n-Succinimidyl) Malonate
CAS No.	30364-59-1
Molecular Formula	C12H10N2O8
Molecular Weight	310.22 g/mol
Synonyms	Disuccinimidyl Malonate; Bis(N-succinimidyl) Malonate; Malonic Acid Bis(N-hydroxysuccinimide) Ester; Malonic Acid Di(N-succinimidyl) Ester; NHS-Malonate-NHS; DSM; BNHS-Malonate; Bis(succinimidyl) Malonate
EINECS	Contact for details

Quality Control

Our Di(n-Succinimidyl) Malonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and FT-IR for identification, to ensure it meets the high standards required for sensitive bioconjugation applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent performance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and reactivity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.