Description

Metacycline Hydrochloride is a semi-synthetic, broad-spectrum antibiotic belonging to the tetracycline class. It is valued for its efficacy against a wide range of Gram-positive and Gram-negative bacteria, mycoplasma, and certain protozoa. This compound is primarily utilized in the pharmaceutical industry for the formulation of veterinary and, in some regions, human medicinal products. Its stability and potency make it a critical active pharmaceutical ingredient (API) for manufacturers requiring reliable antibiotic solutions.

Application

• Veterinary Pharmaceuticals: Primary use in medicated feeds, injectables, and oral formulations for treating bacterial infections in livestock, poultry, and companion animals.
• Human Pharmaceutical Preparations: Used in the synthesis of certain antibiotic formulations, subject to regional pharmacopoeial standards and regulations.
• Research & Development: Serves as a key reference standard and biochemical tool in microbiological and pharmacological research.
• Aquaculture: Employed in treatments for bacterial diseases affecting farmed fish and shellfish.
• API Intermediate: Acts as a starting material or intermediate in the synthesis of more complex tetracycline derivatives.

Basic Information

Product Name	Metacycline Hydrochloride
CAS No.	3963-95-9
Molecular Formula	C22H22N2O8 • HCl
Molecular Weight	478.88 g/mol
Synonyms	Metacycline HCl; 6-Methylene-5-oxytetracycline hydrochloride; Methacycline Hydrochloride; 6-Deoxy-6-demethyl-6-methylene-5-oxytetracycline Hydrochloride; Rondomycin Hydrochloride; Bialatan; Centromycin; Optimycin; Physiomycine
EINECS	223-556-8

Quality Control

Our Metacycline Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with specifications aligning with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA), detailing results for identity, potency, purity, and related substances, is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and potency.

Specification

Item	Specification
Appearance	Yellow to light yellow, crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	95.0% - 102.0% (on anhydrous basis)
pH (1% Solution)	2.0 - 3.5
Water (Karl Fischer)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.