Description

Methacycline Hydrochloride CAS NO 3963-45-9 is a semi-synthetic tetracycline antibiotic derived from oxytetracycline. This compound is valued for its broad-spectrum antibacterial activity against a wide range of Gram-positive and Gram-negative organisms. It is primarily utilized in pharmaceutical research and development for the formulation of antibacterial agents. The product is supplied to meet the stringent quality requirements of the global pharmaceutical and life science industries.

Application

• Pharmaceutical Active Ingredient (API): Used in the research, development, and production of antibacterial medications.
• Veterinary Medicine: Employed in formulations for treating bacterial infections in animals.
• Biochemical Research: Serves as a critical tool in microbiological studies and antibiotic mechanism of action research.
• Reference Standard: Used as a certified reference material in analytical laboratories for quality control and method validation.
• Intermediate Synthesis: Acts as a key starting material or intermediate for further chemical synthesis of novel tetracycline derivatives.

Basic Information

Product Name	Methacycline Hydrochloride
CAS No.	3963-45-9
Molecular Formula	C22H22N2O8 • HCl
Molecular Weight	478.88 g/mol
Synonyms	Methacycline HCl; 6-Methylene-5-hydroxytetracycline hydrochloride; 6-Deoxy-6-demethyl-6-methylene-5-oxytetracycline hydrochloride; Rondomycin Hydrochloride; Metacycline Hydrochloride; BRN 0098562; Adramycin Hydrochloride; GS-2147
EINECS	223-563-1

Quality Control

Our Methacycline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency meet high-grade standards, including potential compliance with pharmacopeial monographs (e.g., USP, EP). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from moisture and direct light exposure to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
pH (1% Solution)	2.0 - 3.5
Water (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.