Description

16α-Hydroxy-6α-Fluoroprednisolone is a fluorinated synthetic corticosteroid derivative, a key intermediate in advanced pharmaceutical synthesis. This compound is valued for its potent glucocorticoid activity and serves as a critical building block for developing novel anti-inflammatory and immunosuppressive agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of advanced corticosteroid drugs with enhanced potency and targeted activity.
• Research & Development: Used in biochemical and pharmacological research to study glucocorticoid receptor interactions and metabolic pathways.
• Anti-inflammatory Agent Development: Serves as a core structure for creating new topical and systemic treatments for inflammatory conditions like dermatitis, arthritis, and asthma.
• Immunosuppressant Synthesis: Employed in the development of agents to manage autoimmune diseases and prevent organ transplant rejection.
• Metabolic Studies: Utilized as a reference standard or probe in studies investigating steroid metabolism and enzymatic transformations.

Basic Information

Product Name	16α-Hydroxy-6α-Fluoroprednisolone
CAS No.	3915-36-4
Molecular Formula	C21H27FO6
Molecular Weight	394.44 g/mol
Synonyms	6α-Fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 6α-Fluoroprednisolone 16α-ol; 16α-Hydroxy-6α-fluoroprednisolone; 6α-Fluoro-16α-methylprednisolone; 9α-Fluoro-16α-methylprednisolone (common alternate numbering); Fluoroprednisolone 16α-hydroxy derivative
EINECS	Contact for details

Quality Control

Our 16α-Hydroxy-6α-Fluoroprednisolone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting research and pharmaceutical intermediate standards. A detailed Certificate of Analysis (COA) documenting purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.