Description

p-Toluenesulfonic Acid 3-Nitrophenyl Ester is a specialized organic synthesis intermediate, primarily valued for its role as an effective sulfonylation and coupling agent. This compound is crucial for introducing the p-toluenesulfonyl (tosyl) protecting group or facilitating the formation of carbon-heteroatom bonds in complex molecular architectures. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for API synthesis and novel compound development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs.
• Protecting Group Reagent: Used to install the tosyl (Ts) protecting group on alcohols and amines during multi-step organic synthesis.
• Cross-Coupling Reactions: Serves as an electrophilic partner in palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Agrochemical Synthesis: Intermediate in the production of herbicides, fungicides, and other crop protection agents.
• Polymer Chemistry: Monomer or modifying agent in the synthesis of specialty polymers and functional materials.
• Dye and Pigment Manufacturing: Used in the synthesis of nitroaryl-based dyes and colorants.
• Research & Development: A valuable tool for method development and exploratory chemistry in academic and industrial R&D laboratories.

Basic Information

Product Name	p-Toluenesulfonic Acid 3-Nitrophenyl Ester
CAS No.	3899-90-9
Molecular Formula	C13H11NO4S
Molecular Weight	277.30 g/mol
Synonyms	3-Nitrophenyl p-Toluenesulfonate; 4-Methylbenzenesulfonic Acid 3-Nitrophenyl Ester; p-Toluenesulfonyl 3-Nitrophenyl Ester; Tosyl 3-Nitrophenyl Ester; 3-Nitrophenyl Tosylate; 1-Nitro-3-(4-methylphenylsulfonyloxy)benzene; 4-Methylbenzenesulfonic Acid 3-Nitrophenyl Ester
EINECS	Contact for details

Quality Control

Our p-Toluenesulfonic Acid 3-Nitrophenyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.