Description

9-Fluoro-11β-Hydroxy-17,20:20,21-Bis(Methylenedioxy)-Pregna-1,4-Dien-3-One is a high-purity synthetic steroid derivative, serving as a critical advanced intermediate in pharmaceutical research and development. Its complex molecular architecture, featuring strategic fluorination and protective groups, makes it invaluable for the synthesis of potent glucocorticoid receptor modulators and other specialized therapeutic agents. This compound is primarily sought by R&D laboratories and fine chemical manufacturers in the pharmaceutical and biotechnology sectors for developing novel anti-inflammatory and immunosuppressive drugs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel glucocorticoid and corticosteroid APIs (Active Pharmaceutical Ingredients).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic candidates with anti-inflammatory properties.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of steroid-based pharmaceuticals.
• Biochemical Research: Utilized as a tool compound in studies investigating steroid hormone receptor binding and signaling pathways.

Basic Information

Product Name	9-Fluoro-11β-Hydroxy-17,20:20,21-Bis(Methylenedioxy)-Pregna-1,4-Dien-3-One
CAS No.	3800-34-8
Molecular Formula	C₂₄H₂₉FO₅
Molecular Weight	416.49 g/mol
Synonyms	9α-Fluoro-11β-hydroxy-17,20:20,21-bis(methylenedioxy)pregna-1,4-dien-3-one; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione cyclic 17,20:20,21-bis(acetal); 9α-Fluoro-11β-hydroxy-16β-methyl-17,20:20,21-bis(methylenedioxy)-1,4-pregnadiene-3-one; 9-Fluoro-11β-hydroxy-16β-methyl-17,20:20,21-bis(methylenedioxy)pregna-1,4-dien-3-one; Bis-Methylenedioxy Derivative of 9α-Fluoro-16β-methylprednisolone; Fluorometholone Intermediate; 3800-34-8
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11β-Hydroxy-17,20:20,21-Bis(Methylenedioxy)-Pregna-1,4-Dien-3-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot. We support development and cGMP-grade requirements, and specifications can be aligned with your project's phase-appropriate needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.