Description

Dehydroepianderosterone Tms is a trimethylsilyl (TMS) derivative of the important steroid hormone precursor dehydroepiandrosterone (DHEA). This chemical modification enhances the compound's volatility and thermal stability, making it a critical analytical standard and intermediate for high-precision research and development. It is primarily utilized by analytical laboratories and pharmaceutical R&D teams working in steroid hormone analysis, metabolic studies, and the development of diagnostic assays. The compound's defined structure ensures reliable and reproducible results in sensitive chromatographic and mass spectrometric applications.

Application

• Gas Chromatography-Mass Spectrometry (GC-MS) Internal Standard: Serves as a crucial reference compound for the quantitative analysis of steroid hormones and their metabolites due to its derivatized, volatile nature.
• Pharmaceutical Research & Development: Used as a key intermediate or reference material in the synthesis and analysis of novel steroid-based therapeutics and diagnostic agents.
• Clinical Diagnostics: Employed in the development and calibration of assays for measuring DHEA and related steroid pathways in biological samples for clinical research.
• Metabolomics and Biomarker Discovery: Acts as a standard in profiling steroid metabolomes to identify biomarkers for endocrine disorders, cancers, and metabolic diseases.
• Forensic Toxicology: Utilized as a reference standard in the confirmation and quantification of anabolic steroids and other banned substances.
• Academic Research: Supports fundamental studies in endocrinology, biochemistry, and steroid hormone action within university and institutional laboratories.
• Quality Control for Reference Material Producers: Used by manufacturers to certify and validate the purity of their own DHEA and steroid-related reference materials.

Basic Information

Product Name	Dehydroepianderosterone Tms
CAS No.	3747-91-9
Molecular Formula	C24H42O2Si2
Molecular Weight	418.77 g/mol
Synonyms	Dehydroepiandrosterone 3,17-bis(trimethylsilyl) ether; 5-Androsten-3β-ol-17-one 3,17-bis-O-(trimethylsilyl); DHEA bis-TMS; DHEA bis(trimethylsilyl) ether; 3β-Hydroxy-5-androsten-17-one bis(trimethylsilyl) ether; Prasterone bis-TMS ether; 3747-91-9; 5-Androsten-3β,17-diol-17-one 3,17-bis(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our Dehydroepianderosterone Tms is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for analytical and research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We support compliance with relevant Good Laboratory Practice (GLP) and quality standards for reference materials. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.