Description

Boc-D-Phe-Osu CAS NO 3674-18-8 is a high-purity, N-Boc-protected amino acid active ester, specifically the N-hydroxysuccinimide ester of Boc-D-phenylalanine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and racemization-free incorporation of D-phenylalanine into peptide chains. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research who require high-fidelity chiral amino acid derivatives for creating novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the controlled, sequential coupling of D-phenylalanine in automated peptide synthesizers.
• Pharmaceutical Intermediate: Used in the research and production of therapeutic peptides, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Peptidomimetic Design: Facilitates the creation of non-natural peptide structures with enhanced stability, bioavailability, and biological activity for drug discovery.
• Bioconjugation: Serves as a linker molecule for attaching peptide motifs to other biomolecules, surfaces, or carrier molecules in biotech applications.
• Academic & Industrial Research: A standard reagent in chemistry and biochemistry laboratories for studying peptide structure-function relationships and developing new synthetic methodologies.
• Production of Chiral Catalysts & Ligands: Used as a precursor for synthesizing chiral auxiliaries and ligands used in asymmetric synthesis.

Basic Information

Product Name	Boc-D-Phe-Osu
CAS No.	3674-18-8
Molecular Formula	C18H22N2O6
Molecular Weight	362.38 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-phenylalanine N-hydroxysuccinimide ester; Boc-D-Phenylalanine OSuc ester; Boc-D-Phe-OSu; (R)-2-((tert-Butoxycarbonyl)amino)-3-phenylpropanoic acid 2,5-dioxopyrrolidin-1-yl ester; N-Boc-D-phenylalanine succinimidyl ester; N-Boc-D-Phe-OSu; N-α-Boc-D-phenylalanine N-hydroxysuccinimide ester; Boc-D-Phenylalanine N-succinimidyl ester
EINECS	Contact for details

Quality Control

Our Boc-D-Phe-Osu is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for sensitive peptide synthesis applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), and specific impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and reliable performance in your processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.