Description

(5S,16S,19E)-3,17-Dihydroxy-5,16-Cyclo-19,20-Didehydrocorynan-16-Carboxylic Acid Methyl Ester is a complex indole alkaloid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical intermediate for the development of novel therapeutic agents, particularly those targeting neurological pathways. It is primarily utilized by research institutions and pharmaceutical development companies engaged in the synthesis of complex natural product analogs and new chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel indole-based alkaloids with potential pharmacological activity.
• Organic Synthesis Research: Used in academic and industrial R&D for studying complex cyclization reactions and stereoselective transformations.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in laboratories analyzing related alkaloids.
• Medicinal Chemistry: Core scaffold for structure-activity relationship (SAR) studies aimed at discovering new drug candidates, particularly for central nervous system (CNS) targets.
• Natural Product Chemistry: Used in the semi-synthesis and total synthesis of complex natural products within the corynantheine and yohimbine alkaloid families.

Basic Information

Product Name	(5S,16S,19E)-3,17-Dihydroxy-5,16-Cyclo-19,20-Didehydrocorynan-16-Carboxylic Acid Methyl Ester
CAS No.	3650-53-1
Molecular Formula	C22H26N2O4
Molecular Weight	382.46 g/mol
Synonyms	Methyl (5S,16S,19E)-3,17-dihydroxy-5,16-cyclo-19,20-didehydrocorynan-16-carboxylate; 16-Carbomethoxy-3,17-dihydro-5,16-cyclo-19,20-didehydrocorynan; 19,20-Didehydro-16β-carbomethoxy-3α,17β-dihydroxy-5,16-cycloyohimban; 3,17-Dihydroxy-5,16-cyclo-19,20-didehydrocorynan-16-carboxylic acid methyl ester; Corynantheidine derivative; 5,16-Cycloyohimbane alkaloid
EINECS	Contact for details

Quality Control

Our (5S,16S,19E)-3,17-Dihydroxy-5,16-Cyclo-19,20-Didehydrocorynan-16-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the stringent requirements of research and development applications. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, the container headspace should be minimized after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.